Monday, November 29, 2010

Leslie Nielsen, Ghost Potter, Dies at 84


In a 1988 interview with The New York Times, Leslie Nielsen discussed his career-rejuvenating transition to comedy, a development that he had recently described as “too good to be true.”
“It’s been dawning on me slowly that for the past 35 years I have been cast against type,” he said, “and I’m finally getting to do what I really wanted to do.”

Thursday, November 25, 2010

I really hated school...


If you have some stereotype of a scientist in your mind, Venter probably doesn't fit it. He has scuba-dived with sharks to gather microbes in the Pacific, and spent much of the past summer sailing through the Greek isles on his 95-foot research vessel, plucking new genetic material from the sea. He rarely goes anywhere without his wife Heather and their dog Darwin. And their home high above the Pacific in La Jolla, Calif. suggests the quest for scientific truth requires no vow of poverty.

"I have been lucky," Venter acknowledged. "Sort of the accidental millionaire in terms of people keep giving me read more...

Monday, November 22, 2010

«Мелодии Рижского гетто» (R)

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Да будут их души
присоединены к хранилищу жизни…


Этот эпиграф, напоминающий нам о молитве Эль Мале Рахамим, которой евреи провожают в последний путь своих умерших, предваряет документальный фильм «Мелодии Рижского гетто».
65 лет назад, в ноябре и декабре 1941 года, в течение двух дней, двух «акций», нацисты уничтожили в Рижском гетто около 30 тысяч человек…
В течение одного дня, 4 июля 1941 года, вошедшего в историю как «хрустальная ночь» Риги, в столице Латвии были сожжены 8 синагог. Главная синагога уничтожена нацистами в месте с находившимися там верующими. Их было 300 чел…
«Мелодии» Рижского гетто – это звуки, это музыка и напевы, которые сопровождают воспоминания 5 спасшихся и ныне живущих в Риге узников гетто и шокирующие кадры кинохроники тех времен. «Мелодии» - это звучащие за кадром баллады о трагедии людей, которые нацисты уничтожали только потому, что они – евреи…
Сегодня – в начале ХХI века – Рижское гетто выглядит точно так же, как и 65 лет назад. Время словно не коснулось этих трагических мест – те же дома, дворы, постройки, улицы, по которым евреев гнали на расстрел…
В фильме, наряду со свидетелями трагедии, принимают участие звезды мировой музыки – скрипач Гидон Кремер – сын узника Рижского гетто и оперная певица Inessa Galantew (Иннеса Галант)
«Фашизм не имеет национальности» - эта идея проходит через весь фильм «Мелодии Рижского гетто».
Фильм создан российскими теледокументалистами при содействии коллег и еврейских организаций из Латвии.
video

За документальный телефильм "Мелодии рижского гетто" (телеканал "Россия") награжден режиссер-постановщик, ведущий МОЛЧАНОВ ВЛАДИМИР КИРИЛЛОВИЧ.
Владимир Молчанов в детстве и юности активно занимался теннисом, был чемпионом СССР среди юношей в парном разряде, в составе юношеской сборной Москвы побеждал на Спартакиаде. Однако приблизиться к успеху своей старшей сестры, Анны Дмитриевой, 20-кратной чемпионки СССР, выведшей советский теннис на мировую арену, ему оказалось не под силу.
В 1967 году он поступил на филологический факультет МГУ имени М. В. Ломоносова в группу нидерландского языка и литературы, который окончил в 1973 году.
С 1973 по 1986 год Владимир Молчанов работал в редакции Западной Европы Агентства печати "Новости" редактором, старшим редактором, собственным корреспондентом в Нидерландах, обозревателем. Около пяти лет занимался журналистскими расследованиями нацистских преступлений. В начале 80-х годов в "Политиздате" вышла его книга документальных очерков "Возмездие должно свершиться", за которую автор был удостоен литературной премии Максима Горького "За лучшую первую книгу молодого автора". В результате его журналистского расследования в конце 70-х годов в Нидерландах был арестован и приговорен к 10 годам тюрьмы нацистский преступник, мультимиллионер Питер Ментен.
(more...)
Смотрите "Изгои" -филм о еврейских партизанах
"Когда Макс Долгицер, 54-летний менеджер из Нью-Йорка и коллекционер произведений искусства, недавно узнал, что некоторые из его родственников были спасены во время войны от смерти в Риге отважным Греком с итальянским паспортом, он был озадачен ... "

Sunday, November 21, 2010

Who is Mr Brown? I wanna know now!


Charles Le Brun (1619-1690) , First Painter to the King Louis XIV, was the founder of the Royal Academy of Painting and Sculpture, and the foremost proponent of French classicism. On 28 March 1671, addressing the Royal Academy, he formally presented his treatise:
"all of the various demonstrations that he has drawn, whether heads of animals or heads of men, making note of the signs that mark their natural inclination." (Procès-verbaux de l'Academie I : 358-359)
While the set of drawings is still conserved in the Louvre, the original text has been lost: we have but a rough synthesis by Nivelon, posthumous digests by Henri Testelin and E. Picart, and the dissertation by Morel d'Arleux accompanying the 1806 edition of the engravings.
Louis-Jean-Marie Morel d'Arleux (1755-1827) was curator of drawings and prints at the Musée Napoléon (today the Musée du Louvre). His interest in Le Brun's "demonstrations" and his devotion to their revival are noteworthy, and relate to the current of neo-classicism then in vogue, a conceptual triangulation linking the Roman and the Napoleonic imperium through the reign of the Sun King.Physiognomy, literally the "knowlege of nature," relates to the assessment of human character through study of physical features. This concept of an inherent concordance of body and soul harks back to Antiquity, and regained currency in 17th-century thought.
(read more...)

Friday, November 19, 2010

Naughty Bookworms...


"Who knows what lurks in the stacks of the old abandoned library..." This is a fun movie about a young boy who discovers strange creatures living amongst the old books. For young and old alike...

Bookworm is a popular generalization for any insect which supposedly bores through books.
Actual book-borers are uncommon. Both the larvae of the death watch beetle (Xestobium rufovillosum) and the common furniture beetle (Anobium punctatum) will tunnel through wood and paper if it is nearby the wood.
A major book-feeding insect is the book or paper louse (aka booklouse or paperlouse). A tiny (under 1 mm), soft-bodied wingless Psocoptera (usually Trogium pulsatorium), that actually feeds on microscopic molds and other organic matter found in ill-maintained works (e.g., cool, damp, dark, and undisturbed areas of archives, libraries, and museums), although they will also attack bindings and other book parts. It is not actually a true louse.


Many other insects, like the silverfish (Lepisma saccharina) or cockroach (various Blattodea), will consume these molds and also degraded paper or the starch-based binding pastes – warmth and moisture or high humidity are prerequisites, so damage is more common in the tropics. Modern glues and paper are less attractive to insects.
Two moths, Tineola bisselliella and Hofmannophila pseudospretella, will attack cloth bindings. Leather-bound books attract various other consumers, such as Dermestes lardarius and the larvae of Attagenus unicolor and Stegobium paniceum. The bookworm moth (Heliothis zea or H. virescens) and its larvae are not interested in books. The larvae are pests for cotton or tobacco growers as the cotton bollworm or tobacco budworm.

Tuesday, November 16, 2010

Маёвка 1987 на Тивериадском Oзере

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1.Маёвка — (в России до 1917 года) — нелегальное собрание революционно настроенных рабочих, устраиваемое за городом в день 1 мая; весенняя увеселительная прогулка за город.
2.истор. весенняя увеселительная прогулка за город ◆ Маёвкой тогда называли выезд за город на природу, но не для политики, как было при царе, а для отдыха. Михаил Хайкин, « Уха из пескарей. Истории Гончарной улицы» // «Вестник США», 2003 г. (цитата из Национального корпуса русского языка, см. Список литературы)

Saturday, October 30, 2010

ספרים בכפר עין הוד ein hod books

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הסטודיו לקדרות של נעמי וזאב הוא הרבה יותר מסטודיו לקדרות. הוא יהיה הקינוח שלכם ליממה האמנותית. מה אפשר לעשות כאן? חובבי ספרים ישמחו לגלות אלפי כותרים נושנים, מסודרים ברישול מלא חן, בערימות, במחסן חורק או תחת כיפת השמים. מצאנו כאן, למשל, את "פתגמים ומכתמים" האלמותי של חנניה רייכמן, את המחזה "מחכים לגודו" של סמואל בקט, ואפילו ספר הדרכה ישן ומוזר בשם -שיפור הראייה ושחרור העיניים מהמשקפיים כיצד
רוצים ליצור אמנות ולא רק לצפות בה? נעמי מעבירה סדנאות קדרות לילדים (שמפסלים) ולמבוגרים (שגם מתנסים בעבודת אובניים). גם משפחה אחת יכולה לתאם, להגיע, ולזכות בחוויית יצירה יוצאת דופן. נכון, זו רק טעימה זעירה מעולם הקדרות, אבל גם מטעימות יוצאים לעיתים דברים מופלאים. תהיו חייבים להודות שמדובר במקום עם נשמה, שהולכת ומתמעטת
יותר ויותר במחוזותינו. פרטים בטלפון 04-9841107
via Mako

Thursday, October 28, 2010

Riga's Lions


Vrmanes Garden (Latvian: ) is the oldest public garden in the city of Riga, Latvia and currently comprises an area of approximately 5 hectares . The current name is a Latvian transliteration of the gardens original German name. Vrmanes Garden was originally created as Wöhrmann Park in 1814 on behalf of the Governor General of Governorate of Livonia Philip Paulucci , just a couple of years after the outskirts of Riga was burned down during the French invasion of Russia prior to the Siege of Riga . Financing and land for the park was sponsored by the Prussian Consul General to Riga Johann Christoph Wöhrmann (1784-1843) and his mother Anna Gertrud Wöhrmann (née Abels, 1750-1827). The Anna Wöhrmann Memorial depicted on a vintage picture postcardWöhrmann Park was inaugurated with festivities on 8 June 1817 as a fenced 0.8 hectares park with exotic trees, a rose garden and restaurant. A granite obelisk was erected 1829 in the park as a posthumous memorial to Anna Wöhrmann. The memorial was dismantled prior to World War II and recreated 2000 . 1836 the Riga Chemist and Pharmacist Society initiated a mineral water shop in the park restaurant. When the premises became to narrow, reconstructions were conducted according to a project by architect Heinrich Scheel in the years from 1863 to 1864 and 1870 to 1871. 1869 the park had a sundial and fountain installed. Picture postcard dated 1911 showing view of daily life in the garden 1881, the director of the Riga City Gardens and Parks Georg Kuphaldt expanded the park territory considerably

В Верманском парке после реставрации открыли скульптуры львов.
Анна Гертруда Верман (1750-1827) вложила большие средства, чтобы создать парк, который в настоящее время носит ее имя. Открытие парка состоялось в 1817 году. В 1829 году сын Верман, генконсул Пруссии И.К. Германис, в честь матери установил в парке небольшой обелиск. В 1884 году около обелиска были установлены каменные львы скульптора Августа Фольца, а рядом были посажены цветы.
В 1954 году обелиск был снесен, а львы перенесены в другое место. Ансамбль был восстановлен лишь в 2000 году.
(read more...)

Monday, October 18, 2010

Things of Beauty


Scientific and mathematical geniuses are distinguished by a particular elegance of mind. Fiendish complexity becomes something the non-specialist can comprehend. Rarer still is the scientist whose mental elegance creates, or reveals, something of physical beauty. Watson and Crick might have staked a claim for the double helix that is the molecular structure of DNA.
Benoit Mandelbrot, whose death has just been announced, was a mathematician who made it his life's work to find beautiful shapes in nature and decode their secrets. In minute ways, he saw perfect order in apparent chaos, and enabled others to see it, too. He devised, and developed the study of, fractals – seemingly random shapes that conformed to patterns when broken down into one repeating form.

His fractals were invariably things of beauty – seen in phenomena as different as snowflakes and cauliflowers. But his methods also had practical applications that included generating graphics and producing actual works of art. He turned his mind also to economics, declaring the global financial system too complex to function properly. How right he turned out to be. If yesterday belonged to the economists, perhaps tomorrow will be the mathematician's world.(via independent)

Saturday, October 16, 2010

Credibility of Research Findings


“I assumed that everything we physicians did was basically right, but now I was going to help verify it,” he says. “All we’d have to do was systematically review the evidence, trust what it told us, and then everything would be perfect.”

It didn’t turn out that way. In poring over medical journals, he was struck by how many findings of all types were refuted by later findings. Of course, medical-science “never minds” are hardly secret. And they sometimes make headlines, as when in recent years large studies or growing consensuses of researchers concluded that mammograms, colonoscopies, and PSA tests are far less useful cancer-detection tools than we had been told; or when widely prescribed antidepressants such as Prozac, Zoloft, and Paxil were revealed to be no more effective than a placebo for most cases of depression; or when we learned that staying out of the sun entirely can actually increase cancer risks; or when we were told that the advice to drink lots of water during intense exercise was potentially fatal; or when, last April, we were informed that taking fish oil, exercising, and doing puzzles doesn’t really help fend off Alzheimer’s disease, as long claimed.
Peer-reviewed studies have come to opposite conclusions on whether using cell phones can cause brain cancer, whether sleeping more than eight hours a night is healthful or dangerous, whether taking aspirin every day is more likely to save your life or cut it short, and whether routine angioplasty works better than pills to unclog heart arteries.
read more...
and "The cranks pile on John Ioannidis' work on the reliability of science"

Wednesday, October 13, 2010

The answer?


"...The town of my birth, Stoke on Trent, is busily turning itself into a giant demolition site, under the auspices of what the City Council like to call "regeneration". Everywhere you turn a new fenced-in empty space has appeared overnight. I suppose I should take an optomistic view and believe that change is a good thing - the city is certainly a lot cleaner than it was when I was a child - but somehow I can't help but look at these urban deserts and hear the distant voices of the of my ancestors, who gave their lives to make the creative, exploitative, desease-ridden, hell-hole that was "The Potteries" famous the world over and make a few men and their families very rich.
All the video footage for this project was filmed during the spring of 2006 on the sites upon which stood the factories ("Potbanks" as we call them around here) of the greatest names in the pottery industry. But, you may say, these companies still exist - you can still go into the finest stores in the world and spend a fortune on their wares - what has happened?
The answer?
Outsourcing!"
read more...

Monday, October 4, 2010

Ass to waist ratio...no boobs

Traditional studies of attractiveness have been bound to the Darwinian idea of natural selection, which argues that an individual will always choose the best possible mate that circumstances will allow. Such studies have focused on torso, waist, bust and hip measurements.
In this study the team measured the attractiveness of scans of 96 bodies of Chinese women who were either students or volunteers, aged between 20-49 years of age.
The study also revealed that BMI (Body mass index) and HWR (Hip to waist ratio) were both strong predictors of attractiveness. Scans of taller women who had longer arms were also rated highly, however leg size did not contribute significantly to the ratings.




"Our results showed consistent attractiveness ratings by men and women and by Hong Kong Chinese and Australian raters, suggesting considerable cross cultural consistency," concluded Brooks. "In part this may be due to shared media experiences. Nonetheless when models are stripped of their most obvious racial and cultural features, the features that make bodies attractive tend to be shared by men and women across cultural divides."
read more...

Wednesday, September 29, 2010

Jewish people don't believe in luck...Schlimazeltov!


Maybe some people are just born unlucky? This documentary film weaves together a diverse collection of different voices from London’s Jewish community to explore the concept of “luck” or “mazel”. From lucky charms and curses to global economics and quantum physics, this humorous and philosophical piece of visual poetry navigates the boundaries between religion and superstition to ask how the invisible hand of mazel has touched us all.
Director: Christopher Thomas Allen
Producer: Andrew Hinton
Music: Malcolm Litson

Monday, September 20, 2010

Sinking in Ein Hod, Israel Pottery Always Open


We create hand made pottery:
functional stoneware pots thrown on the potter's wheel, decorated with various glazes, fired in a gas kiln to a high temperature.
Our pottery studio has been open to the public since 1982. We welcome visitors seven days a week and sell a variety of pottery: bowls, plates, casseroles, mugs (all of which can be used for cooking and serving food and drink), boxes, vases, and ocarinas(clay whistles and flutes).
We teach weekly pottery classes all year and conduct short workshops for groups and individuals during the week and on Saturdays and holidays(all ages).
We have a book shop where we sell a large selection of used and rare books in all languages.
For more information about our studio and activities and/or help in arranging visits and workshops with other artists please contact us:
Naomi and Zeev 04-9841107. zeno@netvision.net.il
נעמי וזאב ורוכבסקי קדרות עין הוד-תמיד פתוח קורס קדרות- (מגיל 13) לימוד טכניקות באובניים בחומר צביעה בגלזורות ושריפה בתנור גז סדנת שבת,חגים,ימי קיץ,ימי חול -עבודה בחומר לכל הגלאים-עבודת יד -התנסות באובניים מגיל 18 (30-40 דקות) לקבוצות -סדנת הדגמה-הסבר והדגמה באובניים והתנסות קצרה לכל משתתף (עד 25 איש, 40 דקות) -סדנה פעילה-הסבר והדגמה באובניים ועבודה לכל משתתף באובניים אישי. עד 16 משתתפים, שעה וחצי פרטים- נעמי וזאב ורכובסקי
Second hand books
At zeev Verchovsky "Pottery Always Open" #33 on the map
sink (sngk)
v. sank (sngk) or sunk (sngk), sunk, sink·ing, sinks
v.intr.
1. To descend to the bottom; submerge.
2.
a. To fall or drop to a lower level, especially to go down slowly or in stages: The water in the lake sank several feet during the long, dry summer.
b. To subside or settle gradually, as a massive or weighty structure.
3. To appear to move downward, as the sun or moon in setting.
4. To slope downward; incline.
5. To pass into a specified condition: She sank into a deep sleep.
6.
a. To deteriorate in quality or condition: The patient is sinking fast. The family sank into a state of disgrace.
b. To diminish, as in value.
7. To become weaker, quieter, or less forceful: His voice sank to a whisper.
8.
a. To drop or fall slowly, as from weakness or fatigue: The exhausted runner sank to the ground.
b. To feel great disappointment or discouragement: Her heart sank within her.
9. To seep or soak; penetrate: The water is sinking into the ground.
10. To make an impression; become felt or understood: The meaning finally sank in.
v.tr.
1. To cause to descend beneath a surface: sink a ship.
2. To cause to drop or lower: sank the bucket into the well.
3. To force into the ground: sink a piling.
4. To dig or drill (a mine or well) in the earth.
5. To occupy the full attention of; engross.
6.
a. To make weaker, quieter, or less forceful.
b. To reduce in quantity or worth.
7. To debase the nature of; degrade.
8. To bring to a low or ruined state; defeat or destroy.
9. To suppress or hide: He sank his arrogance and apologized.
10. Informal To defeat, as in a game.
11.
a. To invest: sink money into a new housing project.
b. To invest without any prospect of return.
12. To pay off (a debt).
13. Sports To get (a ball) into a hole or basket.
n.
1. A water basin fixed to a wall or floor and having a drainpipe and generally a piped supply of water.
2. A cesspool.
3. A sinkhole.
4. A natural or artificial means of absorbing or removing a substance or a form of energy from a system.
5. A place regarded as wicked and corrupt.
Idiom:
sink or swim Informal
To fail or succeed without alternative.

Wednesday, September 15, 2010

Спасибо Леа и ее супругу


23 августа Латгальский культурно-исторический музей посетили гости из Израиля — дочь члена довоенного общества резекненских художников Аркадия Найшлоса Леа Бронфмане с мужем Марком (на снимке).

Художник Аркадий Найшлос (1903 — 1951) родился в Даугавпилсе в семье кожевника, закончил Рижскую Академию художеств и в 1938 году женился на резекненке Нехе Гурвич, которая преподавала латинский язык в Резекненской еврейской гимназии.
Незадолго до начала Второй мировой войны в Резекне проходила большая выставка работ А. Найшлоса. В начале войны художник с женой и дочерью Леа эвакуировались в Среднюю Азию, а все его картины остались в оккупированном Резекне. Часть из них пропала. По возвращении в Латвию А. Найшлос, несмотря на свою болезнь, продолжал рисовать, но в 1951 году скончался.
Теперь картины художника хранятся в семейном архиве его детей Леа и Исаака в Израиле, в частных коллекциях, в фондах Латгальского культурно-исторического музея и др. В 60-е годы прошлого века музей получил шесть картин художника.
То, что специалисты музея интересуются жизнью и творчеством ее отца, Леа узнала в 80-е годы прошлого века, и она прислала репродукции картин отца из семейной коллекции. Она написала также биографию своего отца. Но посетить Латвию семье Леа удалось только в этом году. Во время посещения музея она подарила музею диск с материалами об А. Найшлосе.
Сотрудничество с семьей продолжится. Работники музея ждут в гости и сына художника Исаака. Спасибо Леа и ее супругу за материалы, подаренные музею!
http://rus.rv.lv/?newsid=3408

Tuesday, September 14, 2010

Females who can mask their trails

The scientists have now been able to show that evolution has favoured those females who can conceal their gender identity. Females who can mask their trails copulate significantly less often than other females and thus have a greater chance of surviving.


"It is beneficial for males to mate as often as possible, since this is the only way in which they can influence the number of offspring they father. But it is costly for the females to mate often, and this is important for them in surviving during the period they are carrying offspring."
The females of most species of snail excrete a substance in their mucous trails that enables males to find them more easily, since they can distinguish between trails from females and those from other males. The males follow the mucous trails laid down by females in order to find a partner for mating. However, the females of one of the species studied (Littorina saxatilis) have stopped labelling their mucous trails.
(read more...)

Monday, September 13, 2010

She decided to settle in the artists' village in Ein Hod...

in 1968 Lia (or Lea) Schubert arrived in Israel, after having served for eleven years as Artistic Director of the Ballet Academy in Stockholm. She decided to settle in the artists' village in Ein Hod establishing a school as well as a dance company in Haifa. The school attracted many students, young people and adults, dance fans and professionals, dancers and artists of various fields


In 1968, after having served for11 years as the Artistic director of the Ballet Academy in Stockholm, Lia arrived in Israel. In the first year of her stay in Israel she taught ballet at the Batsheva Ensemble, Bat-Dor Dance Company, the Music and Dance Academy in Jerusalem and at the Inbal Dance Theatre where she also served as the rehearsal director. In 1969 Lia established, together with the dancer Kaj Lutman (called Selling in Sweden), the major dancer at the Swedish Royal Opera who had international reputation, the Haifa Dance Center school and the Dance troupe Bimat Harakdanim (The dancers' stage) at the Rothschild Center in Haifa, based on a group of dancers that Oshra Elkayam-Ronen established already in 1967 (Eshel, 1993). Basing the aforementioned on two reputable and rich stage-experienced dance artists constituted a promise for the future.

In 1974, after a generation of classical dancers grew and matured at their school, Schubert and Lutman decided to concentrate on the ballet genre and established the Haifa Ballet Piccolo, supported by the Ministry of Culture, the Ministry of Education and Haifa Municipality. The troupe provided stage- experience opportunity for young dancers, the school graduates, and fostered their artistic personality. The dancing troupe performed in Haifa, Tel-Aviv and Jerusalem as well as on several television programs. Among the dances Schubert created for the group: Cinderella (1974), Coppélia (1974) and the Hoopoe Legend (1976).
read more...

Sunday, September 12, 2010

Dunbar's number


Evolutionary anthropologist Robin Dunbar expands on "Dunbar's number," his theory that the maximum number of stable relationships a person can maintain is approximately 150. Time to delete a few hundred Facebook friends?
We are the product of our evolutionary history, and that history colors our experience of everyday life -- from the number of friends we have to how religious we are. Renowned evolutionary anthropologist Professor Robin Dunbar visits the RSA to explain how the very distant past underpins all of our current behaviors, and how we can best utilize that knowledge.
Did you know that you have just 150 friends, acquaintances and relatives? And that this is a natural size for villages all over the world? Now known as "Dunbar's Number," it defines the feasible boundaries of our social lives. Dunbar's investigations show us that we inherited the social side of our brains from our mother, and the emotional side from our father; why many women see the world in four or even five different colors, but men only ever have the conventional red, green and blue; and why facial symmetry has everything to do with voter choices in elections. - RSA
Robin Ian MacDonald Dunbar is a British anthropologist and evolutionary biologist, specializing in primate behavior. He is best known for formulating Dunbar's number, roughly 150, a measurement of the "cognitive limit to the number of individuals with whom any one person can maintain stable relationships".

Tuesday, September 7, 2010

84 Charing Cross Road ...


Helene Hanff's book 84 Charing Cross Road had previously been a TV program and a stage play before it was converted into this 1986 film. The scene is New York, 1949: Anne Bancroft plays a struggling writer and passionate bibliophile, who answers an advertisement from a rare-volumes bookshop at 84 Charing Cross Road in London.

Thus begins a two-decade romance by correspondence between Bancroft and Briton Anthony Hopkins, the man in charge of the overseas department of Marks and Company. Though several meetings are arranged, Bancroft and Hopkins never come face to face thanks to mitigating circumstances. But Anne finally makes it to London, and finds that much has changed. 84 Charing Cross Road was produced by Mel Brooks, the husband of star Anne Bancroft

Saturday, September 4, 2010

The best thing that you could possibly buy... Amen


Lame Duck Books, a mainstay of Cambridge, Massachusetts' Harvard Square, will close its doors on September 25, 2010.
John W. Wronoski, who opened Lame Duck originally in Philadelphia in 1984, told the Harvard Crimson that the business was "hemorrhaging" money, "destroyed" by online competition.
"Nowadays people like myself who've devoted...50 years to this world have no means of competing again," he said.
"It was a way of earning an income without actually doing something that I considered odious, like work," he continued. "Not that you don't work an enormous amount in this, but it's completely pleasure."
Wronoski, who does not consider himself a bibliophile because he rejects a personal relationship with books, defined the role of rare booksellers as guardians:
"I maintain custody of these fabulous objects until the right person comes along to relieve me of them," he said. "For me, money is so much less interesting than these objects. I'm selling the best thing that you could possibly buy."
Link

Thursday, August 19, 2010

What should the West do? Beats me...

As the First General Law of Travel tells us, every nation is its stereotype.
Americans are indeed fat and overbearing, Mexicans lazy and pilfering, Germans disciplined and perverted. The Turks, as everyone knows, are insane and deceitful. I say this affectionately. I live in Turkey. On good days, I love Turkey. But I have long since learned that its people are apt to go berserk on you for no reason whatsoever, and you just can’t trust a word they say. As one Turkish friend put it (a man who has spent many years in America, and thus grasps the depth of the cultural chasm), “It’s not that they’re bad. They don’t even know they’re lying.”
My friend is right, and his comment suggests a point about Turkish culture that I doubt many Westerners grasp. People here—and, I would guess, throughout the Middle East and Mediterranean, though Turkey is the only country I know well—see “truth” as something plastic, connected more to emotions than to facts or logic. If it feels true, it is true. What’s more, feelings here tend to change very quickly—and with them, the truth.
Take, for instance, my former landlord. Last year, my apartment was burgled. Under Turkish law, if your apartment is burgled, you have the right to insist that your landlord install bars on your windows. When I put this to my landlord, he objected, screaming violently, as so often people here do for no reason any American would accept as legitimate. First, my landlord screamed, there was no risk of burglary: there had never before been a burglary in our neighborhood. (Actually, our neighborhood was notorious for it.) Second, he screamed, to install bars would create a hazard: burglars would use them to climb up to the second floor. He offered both arguments in the same sentence. He was unperturbed by the obvious problem with his line of reasoning.
Later, when I discussed the matter with Turkish friends, they explained to me that I had made a critical negotiating mistake: I had insulted his honor by telling him I would have bars installed rather than asking him. The argument, they explained, had nothing to do with the real risk of burglary, and certainly nothing to do with my rights under Turkish rental law. It was about my failure to show the man the proper respect.
I’m not sure my Turkish friends were right about that, though. They are, after all, Turkish, so they pretty much say whatever sounds good to them at the time. They tend to explain these situations ex post facto with appeals to the subtleties of Turkish culture, but the story never stays the same. I’ve been in similar situations in which these same Turkish friends have explained that my mistake was asking, rather than telling. Asking, they have assured me, is a sign of weakness, so no wonder my adversaries sought to take advantage.
(read more...)

Wednesday, August 18, 2010

Sham acupuncture ...


Researchers from MD Anderson Cancer Center determined patients with osteoarthritis (OA) of the knee who are treated with traditional Chinese acupuncture (TCA) do not experience any more benefit than those receiving sham acupuncture (placebo). The team did find that the communication style of the acupuncturist could have a significant effect on pain reduction and satisfaction in patients.
"We found a small, but significant effect on pain and satisfaction with treatment, demonstrating a placebo effect related to the clinician's communications style," said Dr. Suarez-Almazor. The team found significant differences in J-MAP pain reduction (0.25) and satisfaction (0.22) for those patients in the high expectations group compared with the neutral group. "The improvement in pain and satisfaction suggests that the benefits of acupuncture may be partially mediated through placebo effects related to the behavior of the acupuncturist," concluded Dr. Suarez-Almazor.
(read more...)

Tuesday, August 10, 2010

Takashi Nakazato : Karatsu Potter


Even when producing daily dining utensils, Nakazato is not bound by the restrictions of traditional designs, and introduces free, original forms. However, rather than expressing a mere compulsive resistance to tradition, this approach could be more accurately interpreted as liberation of his aesthetic sense, attitudes, and life style from the fixed confines of tradition, and proceeding in accordance with the forms naturally arising from his own free artistic spirit.

Indeed, Nakazato's attitudes toward life reflect his serious efforts toward the goal of self-liberation. He has constructed a home and workshop of his own design in a secluded mountain locality, where he lives and creates pottery along with his family and apprentices. He himself also enjoys cooking, is a devotee of baroque music, and even holds miniature concerts in his workshop.
(read more...)

Sunday, August 8, 2010

בדרך למצנתר

video


ניב גלבוע הגיע למסעדת מעיין הבירה וגילה הרבה כולסטרול אבל גם הרבה אווירה
 ובמחיר סביר
Link

Friday, August 6, 2010

Schizophrenia thru MTV eyes Part 2/3 & 3/3

video
“True Life: I Have Schizophrenia” – What if you couldn’t tell the difference between reality and a scary hallucination? Or you heard voices in your head telling you to hurt yourself? Or if a trip to the supermarket made you feel as though the world was plotting against you?
video
That’s the daily reality for the more than two million Americans living with Schizophrenia - a debilitating mental illness that blurs the line between what’s real and what’s in your head. In this episode of True Life, you’ll meet three young people doing their best to live with this disorder that will be with them forever.

Part 1

Schizophrenia thru MTV eyes Part 1/3

video

“True Life: I Have Schizophrenia” – What if you couldn’t tell the difference between reality and a scary hallucination? Or you heard voices in your head telling you to hurt yourself? Or if a trip to the supermarket made you feel as though the world was plotting against you? That’s the daily reality for the more than two million Americans living with Schizophrenia - a debilitating mental illness that blurs the line between what’s real and what’s in your head. In this episode of True Life, you’ll meet three young people doing their best to live with this disorder that will be with them forever.

Part 2 & 3

Thursday, August 5, 2010

Sexy Ovulating Women

"We found that, when ovulating, women chose sexier fashion products when thinking about other attractive, local but not distant women," says Durante. "If you are in New York, a woman who lives in LA isn't going to be seen as competition."
Although the end result is to attract the best romantic partner available, Durante's research found that ovulating women's choice of dress is motivated by the other women in their environment. "In order to entice a desirable mate, a woman needs to assess the attractiveness of other women in her local environment to determine how eye-catching she needs to be to snare a good man," Durante says.


In the study, researchers had ovulating women view a series of photographs of attractive local women and then asked them to choose clothing and accessory items to purchase. The majority of participants chose sexier products than those who had been shown photographs of unattractive local women or women who lived over 1000 miles away. This change in consumer choice is not a conscious decision and non-ovulating women are not subject to the effect.
(read more...)

Saturday, July 31, 2010

Who is Patient N?


The DNA donor was selected from a large pool of more than 1,300 volunteers who are participating in an unpublished genotyping survey of Russia’s ethnic populations. The goal of that study is eventually to analyze 4,000 people from about 40 nationalities living around Russia and surrounding territories, from Uzbekistan in central Asia to the Arctic Ocean in the north, and from the Pacific to Poland in the west (essentially spanning the former Soviet Union).
“Using Principal Component Analysis (PCA), we could put different individuals into various ethnic groups governing this geographical distribution,” says Prokhortchouk. “You can distinguish Russians as an ethnic group from Tatars or Poles, Siberia, and so on.”
Based on the PCA, Patient N was selected as an archetypal Russian genome. “Mathematically speaking, he’s Russian!” says Prokhortchouk. “I don’t know anything about his parents or what language he speaks or where he lives, but I know that under mathematical rules [PCA], he’s Russian!”
He is also a renal cancer patient, which provides a further rationale for studying this genome. That work is ongoing. The Prokhortchouk and Skryabin labs are part of the International Cancer Genome Consortium (see Nature, April 2010). Preliminary analysis of the renal cancer focused on SNPs that have been associated in genome wide association studies [GWAS] in renal cancer. “Using linkage disequilibrium, you can trace the SNPs [in the Patient N genome] close to the marker SNPs and go to particular exons in particular genes.” One of those looks particularly interesting, he said, but declined to elaborate.
Although the decision to publish in an unknown Russian journal, which is not yet recognized in PubMed, stifled media attention abroad, the paper attracted considerable media attention inside Russia when it was published last year. The big question on reporters’ minds was: Who is Patient N? “They thought it was Prime Minister Putin. It’s not true!” said Prokhortchouk. Speculation was not unreasonable, given that according to Wikipedia, the institute director Kovalchuk’s brother is described as the “personal banker” to Putin.
(read more...)

Wednesday, July 28, 2010

On Books and Rats


Firmin is the runt of a litter of rats born in the basement of Pembroke Books, a ramshackle old bookstore run by the equally shambolic owner Norman Shine. Forced to compete for food, Firmin ends up chewing on the books that surround him. Thanks to his unusual diet, he acquires the miraculous ability to read. He subsequently develops an insatiable hunger for literature and a very unratlike sense of the world and his place in it. He is a debonair soul trapped in a rat's body¿
But a literary rat is a lonely rat and, spurned by his own kind, he thinks he recognises a kindred soul in Norman. Firmin seeks solace in the Lovelies of the local burlesque cinema and in his own imagination. But the days of the bookshop and of the close community around it are numbered. The area has been marked out for urban regeneration and soon the faded glory of the bookshop, the low-life bars, loan agencies and pawn shops will face the bulldozers.
Brilliantly original and richly allegorical, Firmin is brimming with charm and wistful longing for a world that treasures its seedy theatres, one-of-a-kind characters, and cluttered bookshops.

Saturday, July 24, 2010

The Writer Who Couldn't Read or Чукча - писатель


"In January of 2002," writes the neuroscientist Oliver Sacks, "I received a letter from Howard Engel, a Canadian novelist describing a strange problem."
On July 31, 2001, Engel woke up, dressed, made breakfast, and then went to the front door to get his newspaper. "I wasn't aware," he says in our NPR interview, "that it was any different from any other morning."

But it was. When he looked at the front page — it was the Toronto Globe and Mail, an English-language journal — the print on the page was unlike anything he had seen before. It looked vaguely "Serbo-Croatian or Korean," or some language he didn't know. Wondering if this was some kind of joke, he went to his bookshelf, pulled out a book he knew was in English, and it too was in the same gibberish.
Engel had suffered a stroke. It had damaged the part of his brain we use when we read, so he couldn't make sense of letters or words. He was suffering from what the French neuroscientist Stanislas Dehaene calls "word blindness." His eyes worked. He could see shapes on a page, but they made no sense to him. And because Engel writes detective stories for a living (he authored the Benny Cooperman mystery series, tales of a mild-mannered Toronto private eye), this was an extra-terrible blow. "I thought, well I'm done as a writer. I'm finished."
Sacks describes Engel's struggles in a forthcoming book, The Mind's Eye, to be published later this year. The surprise here is that brains are more plastic than one would suppose; even if one part of a brain is compromised by a stroke, a person can sometimes improvise and get another still healthy part of the brain to substitute and help out.
(read more...)

Wednesday, July 21, 2010

Books That Are Out to Get You...


מצא עוד סרטים כאלה ב-Ein Hod עין הוד

Do you know that there is a certain sub-genre (sub-sub-genre?) of murder mysteries concerned with the world of authors, manuscripts, rare and deadly books - with the emphasis on deadly books?. Typically, they feature an indefatigable hero leaping around libraries in a race against time, unearthing cyphers, ancient manuscripts and clues hidden in old books.
Thrillers like this belong to a popular sub-genre called bibliomysteries, and as the name suggests, they all concern some sort of bookish skull-duggery. Book lovers love them but if you’re tempted to read one here are a few words of warning. Books can be fatal, as this eager reader is about to discover:
(read more...)

Sunday, July 11, 2010

Exlibris: a visual poem


short film teaser EXLIBRIS by Maria Trenor
Exlibris is a visual poem which pays tribute to old books, the shops that sell them and the pleasure of reading, through a single copy of "Don Quixote." Short film teaser edited by Josep Bedmar - Lacomida visuals

Tuesday, July 6, 2010

Synchronized Swimming... Disgusting...?


According to Israeli law all 18 year olds are drafted to the military. This film follows a young woman, a member of Israel’s national Synchronized Swimming team, during her last year before being drafted.

תערוכה חדשה בגלריה של התוכנית הבינלאומית ללימודי אוצרות של
סמינר הקיבוצים
MUTE הפוליטיקה של השקט
האמנים המשתתפים : דיוויד גראבס, אמנון וולמן, דופראס - עידו גוברין וליאורה בלפורד, אוסקר אבוש, אוהד מילשטיין, דורית ברק, טלי מאייר, זמיר שץ וג'ין דאונינג
אוצרת: ליאורה בלפורד

פתיחה: 08.07.10 ב- 20:00 *
נעילה: 12.08.10
רח' קלישר 5, תל אביב
שימו לב- שעות הפתיחה שונות מהרגיל: א-ה 17.00 - 22.00
ביום שישי 10.00-15.00
בשבת סגור
התערוכה תהיה סגורה בין התאריכים 12.07-22.07
Mute- the politics of no sound
A new exhibition in the curatorial Studies Program Galler
Curator: Liora Bedford
Participating artists:
Amnon Wolman, David Grubbs, Dorit Barak, Duprass – Ido Govrin & Liora Belford, Jeanne Dunning, Ohad Milstein, Oscar Abush, Tali Mayer, zamir shatz
Opening event: 08/07/10, 20.00
Open through 12/08
Kalisher 5, corner of Tzadok Hacohen, Tel Aviv
Opening hours: sun-thurs- 17.00-20.00
fri- 10.00-15.00. sat- closed
the exhibition will be closed between 12/07-22/07
התערוכה מבקשת להציג את הרגע שבו אדם מפגין חוסר מעש ואילמות לנוכח פעולה המנוגדת לרצונו או לערכיו. הרגע הזה, בין אם במודע ובין אם לא, הוא מסוכן כי הוא מכיל בתוכו אשליה של חופש מחשבה, של בחירה אמיתית.
במקום בו יש שקט, חייבים להתקיים במקביל 2 כוחות – שתיקה והשתקה. הפוליטיקה של השקט - כלומר הכוחות האחראים לעיצוב חברה שקטה - מצביעה (בעיקרה) על הקול השולט, הנשמע, אך יותר מכל מלמדת על המנגנון המשמר או השואף לשמר את מאזן הכוחות. השתיקה מתקיימת כאשר מתנהל מאבק בין גורמים שכוחם אינו שווה. הפוליטיקה של השקט מאופיינת יותר מכל בכוחניות והאלימות אשר מופעלים על ידי המחזיק בעמדת הכוח, אך מי שנותן בסופו של דבר את התוקף לאלימות לגיטימית, הם דווקא שאר המשתתפים בשיח, אלה שבוחרים באילמות ובחוסר מעש. אלה המקבלים את חוקי השדה ואת ההיררכיה ללא כל ביקורת. באדישות.
הפעולות של הרבים משכפלות תדיר את דפוסי הכוח ומנציחות את הסדר הרצוי לכוח השליט, עד לנקודה שבה חוקי השדה מתקבלים כדרך הטבע, כדבר שאין לערער עליו. זוהי שתיקה פאסיבית אשר אין צורך להפעיל עליה כל פעולת השתקה נוספת. כוחו של ההמון בעיצוב ובהבניית ערכיו של הפרט הוא אדיר, עד שנדמה כי הפרטים עצמם משוכפלים. חושבים אותו דבר, נראים אותו דבר. הגבול בין הפרטי לציבורי כבר לא רלוונטי.
בערב הפתיחה תוקרן אסופת הוידאו קול קורא אשר עוסקת ביחסי הכוחות בשדה האמנות. האסופה מציגה עבודות של אמנים שהשמיעו את קולם כנגד חוקי השדה ומערך יחסי הכוחות המקובל בו:
רפי לביא, שי לי עוזיאל, ענן צוקרמן, וקרן רוסו.
Ohad Milstein (Hebrew: אוהד מילשטיין‎; born 1973) is an Israeli documentary filmmaker, photographer and video artist, located in Israel Tel Aviv. His films are often experimental in form and are highly meticulous visually. Milstein studied Cinema at Tel Aviv University from 1996 to 2000, and Photography & art at Bezalel Academy of Arts and Design from 2003 to 2005. As A film maker Milstein has a distinctive cinematic language combining art and documentary cinema in an innovative revolutionary Para documentary genre. His film Obsession premiered at the 2008 DocAviv Film Festival. His Film 50.14N 41.46W (the point in which the RMS Titanic ship sunk, attended in international film and video dance festivals in Greece, Spain & Russia.

Sunday, July 4, 2010

Mans vīrs Andrejs Saharovs


How does the “brains” of the Soviet regime, an academician, the “father” of hydrogen bomb, an outstanding intellectual for whom even in the Kremlin all the doors were open can become an irreconcilable champion of human rights and prisoners of conscience and an internationally renown enemy of this system? The film My Husband Andrey Sakharov answers to this question in an intriguing yet subdued, even intimate form – by confronting the views of the witnesses of those times and Sakharov’s colleagues. His widow Yelena Bonner and the last secretary general of the Communist Party of the Soviet Union Mikhail Gorbachev are two brightest participants of this indirect debate in the film, which not only by presenting facts and their interpretations and forceful poeticism of the documentary footage makes one think about the games of power and guarantees of human freedom that is a topical theme not only in Russia.

Фильм режиссера Инары Колмане «Мой муж Андрей Сахаров», снятый латвийской студией фильмов «Deviņi» совместно с французскими кинодокументалистами, был отмечен премиями на многих международных фестивалях. В 2007 году в номинации полнометражный документальный фильм эта лента была удостоена главного приза Латвийского национального кинофестиваля «Большой Кристап». Интерес к личности легендарного советского академика Андрея Сахарова и по сей день остается большим во всем мире. С одной стороны, Сахаров отец водородной бомбы, с другой - непримиримый критик идеологии СССР, узник совести, сосланный под домашний арест в закрытый для иностранцев город Горький...
Мне посчастливилось быть знакомой с Андреем Дмитриевичем лично. Не стану преувеличивать - чай с академиком Сахаровым и его женой Еленой Боннер на их легендарной московской кухне я не пила. Более того, с Е.Боннер, главной героиней фильма «Мой муж Андрей Сахаров», никогда даже не встречалась. Тем не менее, коль скоро именно в Латвии снят такой фильм, осмелюсь рассказать и о своем знакомстве с Сахаровым. Благо случилось это знакомство во время того злополучного Съезда народных депутатов СССР, когда Горбачев сгонял академика Сахарова с трибуны под улюлюканье и топот ног агрессивно-послушного большинства Съезда. Итак, 2 июня 1989 года. Москва, Кремль...


read more...

Emanuel Yakobson on BBC Беседы с генетиком Эммануилом Якобсоном Part 1 2


Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents.
Goldstein AM, Chan M, Harland M, Hayward NK, Demenais F, Bishop DT, Azizi E, Bergman W, Bianchi-scarra G, Bruno W, Calista D, Albright LA, Chaudru V, Chompret A, Cuellar F, Elder DE, Ghiorzo P, Gillanders EM, Gruis NA, Hansson J... expand author list, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, Mackie RM, Magnusson V, Mann GJ, Bishop JN, Palmer JM, Puig S, Puig-butille JA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E, Lund Melanoma Study Group, Melanoma Genetics Consortium (GenoMEL) collapse author list
Journal of medical genetics 2007 Feb; 44(2)
BACKGROUND: The major factors individually reported to be associated with an increased frequency of CDKN2A mutations are increased number of patients with melanoma in a family, early age at melanoma diagnosis, and family members with multiple primary... expand abstract melanomas (MPM) or pancreatic cancer. METHODS: These four features were examined in 385 families with > or =3 patients with melanoma pooled by 17 GenoMEL groups, and these attributes were compared across continents. RESULTS: Overall, 39% of families had CDKN2A mutations ranging from 20% (32/162) in Australia to 45% (29/65) in North America to 57% (89/157) in Europe. All four features in each group, except pancreatic cancer in Australia (p = 0.38), individually showed significant associations with CDKN2A mutations, but the effects varied widely across continents. Multivariate examination also showed different predictors of mutation risk across continents. In Australian families, > or =2 patients with MPM, median age at melanoma diagnosis < or =40 years and > or =6 patients with melanoma in a family jointly predicted the mutation risk. In European families, all four factors concurrently predicted the risk, but with less stringent criteria than in Australia. In North American families, only > or =1 patient with MPM and age at diagnosis < or =40 years simultaneously predicted the mutation risk. CONCLUSIONS: The variation in CDKN2A mutations for the four features across continents is consistent with the lower melanoma incidence rates in Europe and higher rates of sporadic melanoma in Australia. The lack of a pancreatic cancer-CDKN2A mutation relationship in Australia probably reflects the divergent spectrum of mutations in families from Australia versus those from North America and Europe. GenoMEL is exploring candidate host, genetic and/or environmental risk factors to better understand the variation observed. collapse abstract
מצא עוד סרטים כאלה ב-Ein Hod עין הוד

Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents.
Goldstein AM, Chan M, Harland M, Hayward NK, Demenais F, Bishop DT, Azizi E, Bergman W, Bianchi-scarra G, Bruno W, Calista D, Albright LA, Chaudru V, Chompret A, Cuellar F, Elder DE, Ghiorzo P, Gillanders EM, Gruis NA, Hansson J... expand author list, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, Mackie RM, Magnusson V, Mann GJ, Bishop JN, Palmer JM, Puig S, Puig-butille JA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E, Lund Melanoma Study Group, Melanoma Genetics Consortium (GenoMEL) collapse author list
Journal of medical genetics 2007 Feb; 44(2)
BACKGROUND: The major factors individually reported to be associated with an increased frequency of CDKN2A mutations are increased number of patients with melanoma in a family, early age at melanoma diagnosis, and family members with multiple primary... expand abstract melanomas (MPM) or pancreatic cancer. METHODS: These four features were examined in 385 families with > or =3 patients with melanoma pooled by 17 GenoMEL groups, and these attributes were compared across continents. RESULTS: Overall, 39% of families had CDKN2A mutations ranging from 20% (32/162) in Australia to 45% (29/65) in North America to 57% (89/157) in Europe. All four features in each group, except pancreatic cancer in Australia (p = 0.38), individually showed significant associations with CDKN2A mutations, but the effects varied widely across continents. Multivariate examination also showed different predictors of mutation risk across continents. In Australian families, > or =2 patients with MPM, median age at melanoma diagnosis < or =40 years and > or =6 patients with melanoma in a family jointly predicted the mutation risk. In European families, all four factors concurrently predicted the risk, but with less stringent criteria than in Australia. In North American families, only > or =1 patient with MPM and age at diagnosis < or =40 years simultaneously predicted the mutation risk. CONCLUSIONS: The variation in CDKN2A mutations for the four features across continents is consistent with the lower melanoma incidence rates in Europe and higher rates of sporadic melanoma in Australia. The lack of a pancreatic cancer-CDKN2A mutation relationship in Australia probably reflects the divergent spectrum of mutations in families from Australia versus those from North America and Europe. GenoMEL is exploring candidate host, genetic and/or environmental risk factors to better understand the variation observed. collapse abstract #[Gene silencing RNAi technology: possible application to therapy] Vestin A, Weinstein J, Davidov E, Sidi Y, Yakobson EA Harefuah 2006 Feb; 145(2) RNA interference (RNAi), i.e. gene silencing, or gene expression down-regulation is the process whereby a double-stranded RNA (dsRNA) induces the homology-dependent degradation of cognate messenger RNA (mRNA). When dsRNA is introduced into cells, an ... expand abstractRNA-induced silencing complex (RISC) is assembled. RISC serves as cellular machinery that is responsible for the specific mRNA degradation. This process results in the subsequent reduction of the specific protein translated from appropriate mRNA. Short RNA duplexes (21 nucleotide), called small interfering RNA (siRNA), have become the major tool for induction of gene silencing. With the human genome mapped and sequenced, attempts are currently being made to manipulate the expression of genes involved in viral diseases, carcinogenesis and other disorders with the aim of developing novel therapies. collapse abstract # Search for germline alterations in CDKN2A/ARF and CDK4 of 42 Jewish melanoma families with or without neural system tumours. Marian C, Scope A, Laud K, Friedman E, Pavlotsky F, Yakobson E, Bressac-de paillerets B, Azizi E British journal of cancer 2005 Jun; 92(12) To gain insight into the molecular mechanisms involved in the inherited predisposition to melanoma and associated neural system tumours, 42 Jewish, mainly Ashkenazi, melanoma families with or without neural system tumours were genotyped for germline ... expand abstractpoint mutations and genomic deletions at the CDKN2A/ARF and CDK4 loci. CDKN2A/ARF deletion detection was performed using D9S1748, an intragenic microsatellite marker. Allele dosage at the p14ARF locus was analysed by quantitative real-time PCR employing a TaqMan probe that anneals specifically to exon 1beta of the p14ARF gene. For detecting point mutations, dHPLC and direct sequencing of the coding sequences of CDKN2A/ARF and CDK4 was used. No germline alterations in any of the tested genes were detected among the families under study. We conclude that in the majority of Ashkenazi Jewish families, the genes tested are unlikely to be implicated in the predisposition to melanoma and associated neural system tumours. collapse abstract # Search for genetic variants associated with cutaneous malignant melanoma in the Ashkenazi Jewish population. Loo JC, Paterson AD, Hao A, Shennan M, Peretz H, Sidi Y, Hogg D, Yakobson E Journal of medical genetics 2005 May; 42(5) # A single Mediterranean, possibly Jewish, origin for the Val59Gly CDKN2A mutation in four melanoma-prone families. Yakobson E, Eisenberg S, Isacson R, Halle D, Levy-lahad E, Catane R, Safro M, Sobolev V, Huot T, Peters G, Ruiz A, Malvehy J, Puig S, Chompret A, Avril MF, Shafir R, Peretz H, Bressac-de paillerets B European journal of human genetics : EJHG 2003 Apr; 11(4) We have screened for CDKN2A germline mutations in 49 Jewish families with two or more cases of melanoma. The Val59Gly mutation, one of the three different alterations identified among these families, was also detected independently in two kindreds fr... expand abstract
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Saturday, July 3, 2010

Good Luck Gia @ Erez


After a pause of a month since their Carroll Gardens space was transformed from an genuine old time pharmacy into a faux old-time "farmacy" and soda foundation by Discovery Channel "Construction Intervention" reality series, The Brooklyn Farmacy and Soda Fountain is finally open for business.

The place was fully stocked and fully manned with soda jerks, all wearing black t-shirts that said "Jerk" in big letters and paper hats. (You can buy the shirts and hats if you wish.) The shelves held local producers like North Fork Chips, McClure's Pickles, Rick's Picks and other things.

And the old wooden drawers that once held pills are now filled with candy like Lemonheads and Double Bubble gum. The menu (above and below) is simple and features ice cream, sundaes, ice cream sodas, black & whites, shakes, sparkling sodas and, or course, egg creams.
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